Scientific Publications

Lapchak PA.

Efficacy and safety profile of the carotenoid trans sodium crocetinate administered to rabbits following multiple infarct ischemic strokes: a combination therapy study with tissue plasminogen activator. Brain Research. 2010; 1309:136-145.

Manabe H, Okonkwo DO, Gainer JL, Clarke RH, Lee KS.

Protection against focal ischemic injury to the brain by trans-sodium crocetinate. J Neurosurg. 2010; 113:802-809.

Manabe H, Wang Y, Yoshimura R, Cai Y, Fitzgerald M, Clarke R, Lee KS.

Metabolic reflow as a therapy for ischemic brain injury. H. Feng et al. (eds.), Early Brain Injury or Cerebral Vasospasm, Acta Neurochirurgica Supplementum, Vol. 110/2, DOI 10.1007/978-3-7091-0356-2_16, # Springer-Verlag/Wien 2011.

Wang Y, Yoshimura R, Manabe H, Schretter C, Clarke R, Cai Y, Fitzgerald M, Lee KS.

Trans-sodium crocetinate improves outcomes in rodent models of occlusive and hemorrhagic stroke. Brain Research. 2014; 1583:245-254.

Gainer J, Sheehan J, Larner J, Jones D.

Trans sodium crocetinate with temozolomide and radiation therapy for glioblastoma multiforme. J Neurosurf. 2016: JNS515-2693

Sheehan J, Popp B, Monteith S, Toulmin A, Tomlinson J, Martin J, Cifarelli C, Lee DH, Park D.

Trans sodium crocetinate: functional neuroimaging studies in a hypoxic brain tumor: Laboratory investigation. J Neurosurg. 2011; 115:749-753.

Sheehan J, Cifarelli C, Dassoulas K, Olson C, Rainey J, Han S.

Trans-sodium crocetinate enhancing survival and glioma response on magnetic resonance imaging to radiation and temozolomide: Laboratory investigation. J Neurosurg. 2010; 113:234-239.

Sheehan J, Sherman J, Jagannathan J, Dassoulas K, Cifarelli C Olson C, Rainey J, Han S.

Effect of trans sodium crocetinate on brain tumor oxygenation: Laboratory investigation. J Neurosurg. 2009; 111:226–229.

Sheehan J, Ionescu A, Pouratian N, Hamilton DK, Schlesinger D, Oskouian RJ, Sansur C.

Trans sodium crocetinate sensitizes glioblastoma multiforme tumors to radiation. J Neurosurg. 2008; 108:972-978.

Gainer, JL,

Trans-sodium crocetinate for treating hypoxia/ischemia. Expert Opinion on Investigational Drugs. 2008; 17:917-24.

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